ABSTRACT
To study narcotic drug abuse, particularly opiate addiction, and other risk factors in patients with acute cholecystitis. In this prospective cross sectional study, variables such as age, gender, weight, narcotics drug abuse, hormone taking, number of pregnancies, and coexistent diseases were recorded in pre-designed forms for 100 consecutive patients who underwent operation for acute cholecystitis between October 2001 and June 2005 in Imam Reza Hospital, Birjand, Iran. Relevant statistical tests were applied, using SPSS version 13.0. From the studied patients 62 females, 38 males with a mean +/- SD of 60.8 +/- 15.9 years, 66 were underweight, 23 were overweight, and only 11 patients had normal weight. Most of the patients 76 had calculous cholecystitis, of which 50 65.8% were female, and 26 34.2%, were male. Seven females 11%, and 14 males 37% revealed jaundice p<0.002. Most 72% had a history of narcotics abuse, of which 69 95.8% abused opiates constantly, and 3 4.2% abused recreationally. A significant p<0.01 relationship was found between acute cholecystitis and opiate addiction. Opiate addiction was more common in patients from rural areas than urban p<0.03. Seventeen female patients 27.4% had a history of taking oral contraceptives. The patients were mostly from low socio-economic populations, and rural areas. The study revealed that narcotic opiate addiction is a major risk factor for occurrence of acute cholecystitis in this area